Dr. Sarah Langley
Education
| 2003-2007 | BA, Physics and Mathematical Sciences Colby College, Waterville, ME, USA |
| 2007-2008 | MSc, Bioinformatics and Theoretical Systems Biology Imperial College London, London, UK |
| 2008-2012 | PhD, Statistical Genetics and Bioinformatics Imperial College London, London, UK |
Present Appointment
| 2012-2014 | Research Associate Cardiovascular Division, King’s College London, London, UK |
Publications
| 1 | Barwari T, Eminaga S, Mayr U, Lu R, Armstrong PC, Chan MV, Sahraei M, Fernández-Fuertes M, Moreau T, Barallobre-Barreiro J, Lynch M, Yin X, Schulte C, Baig F, Pechlaner R, Langley SR, Zampetaki A, Santer P, Weger M, Plasenzotti R, Schosserer M, Grillari J, Kiechl S, Willeit J, Shah AM, Ghevaert C, Warner TD, Fernández-Hernando C, Suárez Y, Mayr M. Inhibition of profibrotic microRNA-21 affects platelets and their releasate. JCI Insight. 2018 3 : e123335. [Full Text] [PubMed] [DOI] |
| 2 | Langley SR, Willeit K, Didangelos A, Matic LP, Skroblin P, Barallobre-Barreiro J, Lengquist M, Rungger G, Kapustin A, Kedenko L, Molenaar C, Lu R, Barwari T, Suna G, Yin X, Iglseder B, Paulweber B, Willeit P, Shalhoub J, Pasterkamp G, Davies AH, Monaco C, Hedin U, Shanahan CM, Willeit J, Kiechl S, Mayr M. Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques. J Clin Invest. 2017 4 : 1546-1560. [Full Text] [PubMed] [DOI] |
| 3 | Gomes RS, Skroblin P, Munster AB, Tomlins H, Langley SR, Zampetaki A, Yin X, Wardle FC, Mayr M. "Young at heart": Regenerative potential linked to immature cardiac phenotypes. J Mol Cell Cardiol. 2016 92 : 105-108. [Full Text] [PubMed] [DOI] |
| 4 | Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K, Morton AC, Armstrong PC, Chan MV, Lu R, Yin X, Gracio F, Dudek K, Langley SR, Zampetaki A, de Rinaldis E, Ye S, Warner TD, Saxena A, Kiechl S, Storey RF, Mayr M. Association of MicroRNAs and YRNAs With Platelet Function. Circ Res. 2016 118 : 420-432. [Full Text] [PubMed] [DOI] |
| 5 | Zampetaki A, Willeit P, Burr S, Yin X, Langley SR, Kiechl S, Klein R, Rossing P, Chaturvedi N, Mayr M. Angiogenic MicroRNAs Linked to Incidence and Progression of Diabetic Retinopathy in Type 1 Diabetes. Diabetes. 2016 65 : 216-227. [Full Text] [PubMed] [DOI] |
| 6 | Langley SR, Mayr M. Comparative analysis of statistical methods used for detecting differential expression in label-free mass spectrometry proteomics. J Proteomics. 2015 129 : 83-92. [Full Text] [PubMed] [DOI] |
| 7 | Zampetaki A, Attia RQ, Mayr U, Gomes RS, Phinikaridou A, Yin X, Langley S, Willeit P, Lu R, Fanshawe B, Fava M, Barallobre-Barreiro J, Molenaar C, So PW, Abbas A, Jahangiri M, Waltham M, Botnar R, Smith A, Mayr M. Role of miR-195 in Aortic Aneurysmal Disease. Circ Res. 2014 115 : 857-866. [Full Text] [PubMed] [DOI] |
| 8 | Goedeke L, Salerno A, Ramírez CM, Guo L, Allen RM, Yin X, Langley SR, Esau C, Wanschel A, Fisher EA, Suárez Y, Baldán A, Mayr M, Fernández-Hernando C. Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice. EMBO Mol Med. 2014 18 : 1133-1141. [Full Text] [PubMed] [DOI] |
| 9 | Cuello F, Shankar-Hari M, Mayr U, Yin X, Marshall M, Suna G, Willeit P, Langley SR, Jayawardhana T, Zeller T, Terblanche M, Shah AM, Mayr M. Redox-state of pentraxin 3 as a novel biomarker for resolution of inflammation and survival in sepsis. Mol Cell Proteomics. 2014 13 : 2545-2557. [Full Text] [PubMed] [DOI] |
| 10 | Stegemann C, Pechlaner R, Willeit P, Langley S, Mangino M, Mayr U, Menni C, Moayyeri A, Santer P, Rungger G, Spector TD, Willeit J, Kiechl S, Mayr M. Lipidomics Profiling and Risk of Cardiovascular Disease in the Prospective Population-Based Bruneck Study. Circulation. 2014 129 : 1821-1831. [Full Text] [PubMed] [DOI] |
| 11 | Beyer C, Zampetaki A, Lin NY, Kleyer A, Perricone C, Iagnocco A, Distler A, Langley SR, Gelse K, Sesselmann S, Lorenzini R, Niemeier A, Swoboda B, Distler JH, Santer P, Egger G, Willeit J, Mayr M, Schett G, Kiechl S. Signature of circulating microRNAs in osteoarthritis. Ann Rheum Dis. 2014 Epub ahead : . [Full Text] [PubMed] [DOI] |
| 12 | El Azzouzi H, Leptidis S, Dirkx E, Hoeks J, van Bree B, Brand K, McClellan EA, Poels E, Sluimer JC, van den Hoogenhof MM, Armand AS, Yin X, Langley S, Bourajjaj M, Olieslagers S, Krishnan J, Vooijs M, Kurihara H, Stubbs A, Pinto YM, Krek W, Mayr M, da Costa Martins PA, Schrauwen P, De Windt LJ. The Hypoxia-Inducible MicroRNA Cluster miR-199a~214 Targets Myocardial PPARdelta and Impairs Mitochondrial Fatty Acid Oxidation. Cell Metab. 2013 18 : 341-354. [Full Text] [PubMed] [DOI] |
| 13 | Abonnenc M, Nabeebaccus AA, Mayr U, Barallobre-Barreiro J, Dong X, Cuello F, Sur S, Drozdov I, Langley S, Lu R, Stathopoulou K, Didangelos A, Yin X, Zimmermann WH, Shah AM, Zampetaki A, Mayr M. Extracellular Matrix Secretion by Cardiac Fibroblasts: Role of microRNA-29b and microRNA-30c. Circ Res. 2013 113 : 1138-1147. [Full Text] [PubMed] [DOI] |
| 14 | Willeit P, Zampetaki A, Dudek K, Kaudewitz D, King A, Kirkby NS, Crosby-Nwaobi R, Prokopi M, Drozdov I, Langley SR, Sivaprasad S, Markus HS, Mitchell JA, Warner TD, Kiechl S, Mayr M. Circulating microRNAs as novel biomarkers for platelet activation. Circ Res. 2013 112 : 595-600. [Full Text] [PubMed] [DOI] |
| 15 | Yin X, Dwyer J, Langley S, Mayr U, Xing Q, Drozdov I, Nabeebaccus A, Shah A, Madhu B, Griffiths J, Edwards LM, Mayr M. Effects of Perhexiline-Induced Fuel Switch on the Cardiac Proteome and Metabolome. J Mol Cell Cardiol. 2013 55 : 27-30. [Full Text] [PubMed] [DOI] |
| 16 | Stegemann C, Didangelos A, Barallobre-Barreiro J, Langley S, Mandal K, Jahangiri M, Mayr M. Proteomic Identification of Matrix Metalloproteinase Substrates in the Human Vasculature. Circ Cardiovasc Genet. 2013 6 : 106-117. [Full Text] [PubMed] [DOI] |
| 17 | Langley SR, Dwyer J, Drozdov I, Yin X, Mayr M. Proteomics: from single molecules to biological pathways. Cardiovasc Res. 2013 97 : 612-622. [Full Text] [PubMed] [DOI] |
| 18 | Lin B, Huntley D, Abuali G, Langley SR, Sindelar G, Petretto E, Butcher S, Grimm S. Determining signalling nodes for apoptosis by a genetic high-throughput screen. PLoS One. 2011 6 : e25023. [PubMed] [DOI] |
| 19 | Bottolo L, Chadeau-Hyam M, Hastie DI, Langley SR, Petretto E, Tiret L, Tregouet D, Richardson S. ESS++: a C++ objected-oriented algorithm for Bayesian stochastic search model exploration. Bioinformatics. 2011 27 : 587-588. [PubMed] [DOI] |
| 20 | Heinig M, Petretto E, Wallace C, Bottolo L, Rotival M, Lu H, Li Y, Sarwar R, Langley SR, Bauerfeind A, Hummel O, Lee YA, Paskas S, Rintisch C, Saar K, Cooper J, Buchan R, Gray EE, Cyster JG; Cardiogenics Consortium, Erdmann J, Hengstenberg C, Maouche S, O. A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk. Nature. 2010 467 : 460-464. [PubMed] [DOI] |
| 21 | Petretto E, Bottolo L, Langley SR, Heinig M, McDermott-Roe C, Sarwar R, Pravenec M, Hübner N, Aitman TJ, Cook SA, Richardson S. New insights into the genetic control of gene expression using a Bayesian multi-tissue approach. PLoS Comput Biol. 2010 6 : e1000737. [PubMed] [DOI] |
| 22 | Stylianou IM, Langley SR, Walsh K, Chen Y, Revenu C, Paigen B. Differences in DBA/1J and DBA/2J reveal lipid QTL genes. J Lipid Res. 2008 49 : 2402-2413. [PubMed] [DOI] |
| 23 | Nishihara E, Tsaih SW, Tsukahara C, Langley S, Sheehan S, DiPetrillo K, Kunita S, Yagami K, Churchill GA, Paigen B, Sugiyama F. Quantitative trait loci associated with blood pressure of metabolic syndrome in the progeny of NZO/HILtJxC3H/HeJ intercrosses. Mamm Genome. 2007 18 : 573-583. [PubMed] [DOI] |